jondoeuk
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Everything posted by jondoeuk
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Its a nonsteroidal antiandrogen and has a different mechanism of action to fin/dut (5AR inhibitors). I still think it could be useful to some as an adjunct.
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The difference was not statistically significant but those given pyril had a positive trend (in non-vellus target area hair counts). I still wonder why the placebo group did so well.
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Kintor Pharma will bring it to market as a cosmetic (likely 0.5%) Cosmetics With KX-826 As The Main Ingredient Launch To Market_Kintor Pharmaceutical Limited
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ProStrakan, the company that eventually acquired the rights to PSK-3841 (aka RU-58841), ran two clinical trials in humans in the early to mid 2000s. The first was a PhI (n=30) and the second was a randomised and placebo controlled PhII (n=120), but results were never published, nor did a pivotal trial start to bring it to market. Now we have (non-)steroidal antiandrogens with published clinical data, which are fluridil, clascoterone (CB-03-01) and pyrilutamide.
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Tretinoin upregulates follicular sulfotransferase enzymes, which metabolise minoxidil to its active metabolite, minoxidil sulfate Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - Sharma - 2019 - Dermatologic Therapy - Wiley Online Library
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Post-Finasteride syndrome discussion on Peter Attila's podcast
jondoeuk replied to Rex99's topic in Hair Loss Drugs
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It (5 mg) was first approved by the FDA for treatment of benign prostatic hyperplasia (prostate enlargement) back in 1992. This is an interesting study on the nocebo effect https://academic.oup.com/jsm/article-abstract/4/6/1708/6890112
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The current version is 2%, but I know actifolic are selling 5%, 8% or 10%, which could improve efficacy.
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From eucapil-shop?
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Everything You Need To Know About Topical Dutasteride
jondoeuk replied to Melvin- Admin's topic in Hair Loss Drugs
Has anyone used dutagen by hemiacosmetics or duderma by minoxidilmax? -
I'll leave this
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No, the grey market. Also, it is generally well-tolerated, with the most common adverse events being localised, such as contact dermatitis.
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Thanks. Do you know about some of the others, such as dutagen and lrak tech?
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From this: ''Sexual functions, libido, hematology, and blood chemistry values were normal throughout, except that at 3 months, in the spring, serum testosterone increased within the normal range equally in placebo and fluridil groups. No fluridil or its decomposition product, BP-34, was detectable in the serum at 0, 3, or 90 days.'' Fluridil, a Rationally Designed Topical Agent for Androgenet... : Dermatologic Surgery (lww.com) I'm not aware of the company behind CosmeRNA doing the same.
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Anyone using duderma?
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Anyone used it? If so, results and any sides?