Senior Member Cant decide Posted April 30, 2013 Senior Member Share Posted April 30, 2013 Does it make more sense to stay on 1.25 mg finasteride daily in addition to 0.5 mg dutasteride once weekly. or 0.5 mg dutasteride twice weekly and discontinuing finasteride. Due to its half life, I dont see a reason to use dut every day. Thoughts? My Hairloss Web Site - Procedure #1: 5229 Grafts with Dr. Rahal Oct, 2010 Procedure #2: 2642 Grafts with Dr. Rahal Aug, 2013 7871 Grafts http://www.hairtransplantnetwork.com/blog/home-page.asp?WebID=2452 Link to comment Share on other sites More sharing options...
mehnajkalra Posted May 4, 2013 Share Posted May 4, 2013 A study published by Olsen et. al. in the Journal of the American Academy of Dermatology 2006; 55(6): 1014-1023, showed the benefit of combined type I and type II 5?-reductase inhibition in the treatment of male pattern hair loss in a randomized, placebo-controlled study of dutasteride versus finasteride. In the study, 416 men with male pattern hair loss (MPHL) ages 21 to 45 years old were randomized to receive dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks. The results of the study showed that dutasteride increased hair counts in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride 5mg at 12 and 24 weeks. Dutasteride caused scalp and serum dihydrotestosterone levels to decrease and testosterone levels to increase in a dose-dependent fashion. Whereas 5-mg finasteride decreases serum DHT by about 70%, dutasteride can decrease serum DHT by more than 90%. In this phase II, dose-ranging study, 2.5-mg dutasteride was superior to 5-mg finasteride in improving scalp hair growth in men between ages 21 and 45 years with MPHL as judged by target area hair counts, expert panel assessment, and investigator assessment at 12 and 24 weeks. Link to comment Share on other sites More sharing options...
Senior Member KO Posted May 4, 2013 Senior Member Share Posted May 4, 2013 I pick the first option. You should take something everyday, as you want your hormones to stay stable. Don't depend on half-life. fin x 6 + dut x1 per week is slightly stronger than fin ED. Dut 2x a week, I have no idea. 3382 FUE Lupanzula http://www.hairrestorationnetwork.com/eve/185463-3382-grafts-lupanzula.html Link to comment Share on other sites More sharing options...
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