Regular Member _lshy Posted January 30, 2022 Regular Member Share Posted January 30, 2022 (edited) When looking at topical anti-androgens to either stack alongside a 5AR inhibitor or run by themselves, the "mide" family seems to be very interesting. Wondering what people's thoughts are on these compounds, experiences and so on. RU-58841 Abandoned Structurally related to the below compounds Pyrilutamide Unreleased Currently in Phase 3 trials for AGA Flutamide Eulexin Used for female hair loss Off-label topical for AGA Topilutamide Fluridil Eucapil Used for female hair loss Off-label topical for AGA Clascoterone Winlevi Breezula With Flutamide being the cheapest and most easily attainable (I could be wrong), has anyone tried home-brewed formulations of it as a topical? What have been the effects/side effects for you? Edited January 30, 2022 by _lshy Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted January 30, 2022 Administrators Share Posted January 30, 2022 Watch this interview with Dr. Hasson on his new topical finasteride. Aside from finasteride, the most compelling future treatment is breezula. https://www.instagram.com/tv/CXUa2QpAjkm/?utm_medium=copy_link I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member _lshy Posted January 30, 2022 Author Regular Member Share Posted January 30, 2022 8 minutes ago, Melvin- Moderator said: Watch this interview with Dr. Hasson on his new topical finasteride. Aside from finasteride, the most compelling future treatment is breezula. https://www.instagram.com/tv/CXUa2QpAjkm/?utm_medium=copy_link Thanks for this, will watch it. I believe you can buy Clascoterone cream now to DIY Breezula though I think it's questionable in potency when compared to other anti-androgens (Topilutamide, etc). Topical finasteride (and dutasteride when combined with microneedling) have been shown to be effective in studies - but they aren't technically anti-androgens and instead block 5AR reduction at the follicle (without significant systemic absorption) which is great for minimising systemic effects in those not interested in taking it orally. For those who tolerate 5AR inhibitors well and are looking to stack a topical anti-androgen alongside their daily finasteride or dutasteride, either temporarily (PED users) or long term (people who want fin/dut to work for a longer time), such application is likely redundant and offers no additional benefits. Link to comment Share on other sites More sharing options...
Senior Member mmokin Posted January 30, 2022 Senior Member Share Posted January 30, 2022 21 minutes ago, Melvin- Moderator said: Watch this interview with Dr. Hasson on his new topical finasteride. Aside from finasteride, the most compelling future treatment is breezula. https://www.instagram.com/tv/CXUa2QpAjkm/?utm_medium=copy_link why is RU not a good choice? doesnt it work the same as breezula? Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted January 30, 2022 Administrators Share Posted January 30, 2022 13 hours ago, mmokin said: why is RU not a good choice? doesnt it work the same as breezula? Personally, it gave me side effects, and ive heard concerns about issues with the heart. I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Senior Member mmokin Posted January 30, 2022 Senior Member Share Posted January 30, 2022 58 minutes ago, Melvin- Moderator said: Personally, it gave me side effects, and ive heard concerns about issues with the heart. do you think it gives more sides since its stronger than breezula and that breezula at a higher dose would have the same sides or is it less selectively targeting androgen receptors which is why it is giving more sides? Link to comment Share on other sites More sharing options...
Senior Member Curious25 Posted January 30, 2022 Senior Member Share Posted January 30, 2022 15 hours ago, _lshy said: Pyrilutamide Unreleased Currently in Phase 3 trials for AGA This has the most promise and potential in my mind. Hopefully we will have access to the phase 2 safety data v soon. I think when one understands the mechanisms of how topical AA's work - if proven to be safe, and efficacious, there wouldn't really be a market for 5AR inhibiters ever again. Link to comment Share on other sites More sharing options...
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