Regular Member Eli_Avdikian Posted August 6 Regular Member Share Posted August 6 As some of you might already know, I am a big proponent of medical therapy for MPB, myself following for some time now a regimen that includes oral dutasteride 0.5 mg daily, in conjunction with oral minoxidil 5mg daily. My story with hair loss medications has been very long and complicated, and I literally tried everything under the sun from topical minoxidil, to topical finasteride and dutasteride to no avail. My history with oral medication is the following : - I started oral minoxidil in March 2023, taking 1.25 mg daily for a month, and then switching to 2.5 mg daily. - I upped my oral minoxidil dose to 5 mg per day in October 2023 - I started oral dutasteride in November 2023, working my up very gradually from one 0.5 mg capsule a week to 7 times a week ( passing through all intermediate doses such as 2 capsules a week, 3 capsules a week, etc) I am posting some progression pictures since I find them to be rather impressive. Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 The crown on topical treatments (before) : Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 The crown on oral medication (after) : Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 (edited) mid-scalp before (my hairline is transplanted) : Edited August 11 by Eli_Avdikian Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted August 6 Regular Member Share Posted August 6 (edited) . Edited August 6 by Fox243 Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 (edited) mid-scalp after : Edited August 11 by Eli_Avdikian Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted August 6 Regular Member Share Posted August 6 When would you say you got noticeable results on the crown? Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 3 minutes ago, Fox243 said: When would you say that you saw noticeable results on the crown? Results on oral minoxidil were quite slow. But within 3 months of taking oral dutasteride, i started seeing a very pronouned difference on the crown 1 Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 6 Author Regular Member Share Posted August 6 I forgot to mention. No side effects whatsoever Link to comment Share on other sites More sharing options...
Regular Member Ccd99 Posted August 7 Regular Member Share Posted August 7 These are some very impressive results! Surely you will continue to see effects as Dutasteride takes a very long time before it reaches max blood concentration levels at 0.5mg and once per day (I think somewhere in the region of 10-12 months). Be prepared for more improvement 1 Consultation with Dr Bruno Ferreira - Nov 2023 - ✅ - see link below for more info First surgery with Dr Bruno Ferreira - Sept 2024 - ✅ - 3200 grafts to frontal third and partial mid-scalp - link to thread Second surgery with Dr Bruno Ferreira - May 2025 - ❌ - 2500-3000 grafts to remainder of mid-scalp and crown + touch-up Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 7 Author Regular Member Share Posted August 7 18 minutes ago, Ccd99 said: These are some very impressive results! Surely you will continue to see effects as Dutasteride takes a very long time before it reaches max blood concentration levels at 0.5mg and once per day (I think somewhere in the region of 10-12 months). Be prepared for more improvement Thanks bro ! Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 7 Author Regular Member Share Posted August 7 A new picture that I took just today Link to comment Share on other sites More sharing options...
Senior Member xabi86 Posted August 8 Senior Member Share Posted August 8 @Eli_Avdikian Thank you for your post. Very helpful. Topical Finasteride or Dutasteride didn't work at all for you? I am using topical fin from Farmacia Parati at the moment and I was speaking to a very well renowned european doctor's patient rep and he said any topical fin or dutasteride is a "waste of time and money". That has really got me worried now. Thinking of trying Dutasteride tablets now, given the whole reason why I switched to topical (0.01% fin) from Farmacia Parati was because I experienced sides from Finasteride. Did you get any sides from Dutasteride (tablets)? 1 Dr Rahal 3581 Grafts (FUT - June 2015) https://www.hairrestorationnetwork.com/topic/42645-dr-rahal-fut-3581-grafts/ Dr Rahal 1787 Grafts (FUE) Crown - Dec 18 https://www.hairrestorationnetwork.com/topic/53113-2nd-round-with-dr-rahal-1787-grafts-fue-fanastic-experience/?do=findComment&comment=502478 Link to comment Share on other sites More sharing options...
Regular Member LeveledUp Posted August 9 Regular Member Share Posted August 9 Man maybe it’s time for me to make leap to Dut. i don’t think oral min 5mg and fin 1mg is doing anything for me regrowth wise 1 Link to comment Share on other sites More sharing options...
Regular Member arthurSam Posted August 9 Regular Member Share Posted August 9 Fake pics lol 1 Minoxidil : 5% topical 1ml/day (with Melatonin 0.0033%, Fisetin 1%, Resveratrol 2%, NMN 1%, Ginko 1%, Caffein 0.2%) DHT and Follicular androgen receptor inhibitor : Topical dutasteride 0.05% twice a week + Fluridil + Pyrilutamide Koshine826 Exosome Mesotherapy 1mm : human Umbilical Chord Exosomes ; see my progress pics here. Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 On 8/9/2024 at 12:40 AM, xabi86 said: @Eli_Avdikian Thank you for your post. Very helpful. Topical Finasteride or Dutasteride didn't work at all for you? I am using topical fin from Farmacia Parati at the moment and I was speaking to a very well renowned european doctor's patient rep and he said any topical fin or dutasteride is a "waste of time and money". That has really got me worried now. Thinking of trying Dutasteride tablets now, given the whole reason why I switched to topical (0.01% fin) from Farmacia Parati was because I experienced sides from Finasteride. Did you get any sides from Dutasteride (tablets)? I think the patient rep is right. I wouldn't have peronsally put it this way, but topicals' efficacy is very limited, if any. Plus, they haven't been researched as well as oral 5AR, nor have they been prescribed to patients on a regular basis for a suffciently long time. All topicals suffer inherently from one main shortcoming, that is, difficulty penetrating the scalp. Most of them are insanely expensive, which explains the "waste of money " bit. Oral dutasteride or finasteride are extremely cheap in comparison. Topical 5AR should only be presribed to patients who absolutely refuse to be on oral medication, and never as a first line of defense against AGA. I haven't benifited personally from any of the topical drugs I've been on. Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 Of course ArthurSam is going to claim that my results are fake since I called out his BS on "exosome treatment" Link to comment Share on other sites More sharing options...
Senior Member xabi86 Posted August 11 Senior Member Share Posted August 11 5 minutes ago, Eli_Avdikian said: I think the patient rep is right. I wouldn't have peronsally put it this way, but topicals' efficacy is very limited, if any. Plus, they haven't been researched as well as oral 5AR, nor have they been prescribed to patients on a regular basis for a suffciently long time. All topicals suffer inherently from one main shortcoming, that is, difficulty penetrating the scalp. Most of them are insanely expensive, which explains the "waste of money " bit. Oral dutasteride or finasteride are extremely cheap in comparison. Topical 5AR should only be presribed to patients who absolutely refuse to be on oral medication, and never as a first line of defense against AGA. I haven't benifited personally from any of the topical drugs I've been on. Thanks @Eli_Avdikian you got no sides with dut right. Did you get them on fin tablets? thinking of trying dut oral given I had sides on fin oral. Dr Rahal 3581 Grafts (FUT - June 2015) https://www.hairrestorationnetwork.com/topic/42645-dr-rahal-fut-3581-grafts/ Dr Rahal 1787 Grafts (FUE) Crown - Dec 18 https://www.hairrestorationnetwork.com/topic/53113-2nd-round-with-dr-rahal-1787-grafts-fue-fanastic-experience/?do=findComment&comment=502478 Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 1 minute ago, xabi86 said: Thanks @Eli_Avdikian you got no sides with dut right. Did you get them on fin tablets? thinking of trying dut oral given I had sides on fin oral. I never tried oral fin. Jumped directly to oral dut. An luckily I haven't had any sides Link to comment Share on other sites More sharing options...
Senior Member xabi86 Posted August 11 Senior Member Share Posted August 11 3 minutes ago, Eli_Avdikian said: I never tried oral fin. Jumped directly to oral dut. An luckily I haven't had any sides What do you reckon, worth trying dut if I got sides on fin? Are there any people who got sides on fin but didn’t on dut. please any advice would be helpful Dr Rahal 3581 Grafts (FUT - June 2015) https://www.hairrestorationnetwork.com/topic/42645-dr-rahal-fut-3581-grafts/ Dr Rahal 1787 Grafts (FUE) Crown - Dec 18 https://www.hairrestorationnetwork.com/topic/53113-2nd-round-with-dr-rahal-1787-grafts-fue-fanastic-experience/?do=findComment&comment=502478 Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted August 11 Regular Member Share Posted August 11 (edited) 2 minutes ago, xabi86 said: What do you reckon, worth trying dut if I got sides on fin? Are there any people who got sides on fin but didn’t on dut. please any advice would be helpful might as well try but its extremely likely you will get sides on dut if you got sides on fin and could take a few months for the sides to wash out (given the long half life). Edited August 11 by Fox243 Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 @Fox243 What makes you so sure? Just because Dut is the stronger drug doesn't mean that it is more likely to cause sides, quite the contrary. The fact that it inhibits both type I and II of 5ARs and has a longer half life means there is potentially less room for hormonal inbalances and fluctuations. I could link the famous Sergio Vaño video that Melvin posted talking about low-dose oral Dut. Maybe, just maybe, @xabi86 could benefit from trying it Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted August 11 Regular Member Share Posted August 11 1 minute ago, Eli_Avdikian said: @Fox243 What makes you so sure? Just because Dut is the stronger drug doesn't mean that it is more likely to cause sides, quite the contrary. The fact that it inhibits both type I and II of 5ARs and has a longer half life means there is potentially less room for hormonal inbalances and fluctuations. I could link the famous Sergio Vaño video that Melvin posted talking about low-dose oral Dut. Maybe, just maybe, @xabi86 could benefit from trying it I mean blocking 5aR type 1 isn't a good thing lol. It's abundantly expressed in the brain and there's not natural occurences/long term research of it, unlike fin. And with fin, there's not really hormonal imbalances/fluctations because even though the drug half life in the blood is like half a day, it is 4-5 days in the tissue, which is what matters. But I don't want to go down this rabbit hole again. Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 Not sure this is relevant because the brain is protected by the blood-brain barrier. It would be hard for a large molecule such as Dut to cross it. Plus inhibiting 5AR in the brain isn't necessarily a bad thing. It's isn't even established that inhibiting pregnenlone is deterimental to mental health, not to mention the conflicting reports that say that it might even be beneficial Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted August 11 Author Regular Member Share Posted August 11 Anyway, all of this is just pure theoretical speculation. All studies prove that dut has the same, if not better, safety profile than fin. Many clinical practionners and patients' anectdotes support this as well (if you care to search on the web) Link to comment Share on other sites More sharing options...
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