TOPICAL DUTASTERIDE DOESNT MAKE SENSE(HELP ME UNDERSTAND PLS)

[dizzydap]

Dutasteride molecular weight is 528.5 g/mol

Dalton rule states the molecule needs to be under 500g/mol in order to penetrate skin

Your thoughts??

[4chanhrn]

It penetrates but not enough. That incombination with dutasteride pharmacokynetics means it can work really well with low systemic absorption.

You might find this post of my on Tressless Community interesting. I've tried to explain topical dutasteride in detail.

 

Edited August 18 by 4chanhrn

[arthurSam]

Weight is not all, there also size wich is important. And Dalton rule is not a binary rule : it's not 0 or 1.

When encapsuling dutasteride molecule within some vehicule, like lipidic carrier nanoemulsion, total molecule size are about 250 nm and can penetrate the skin:

 

Example of a nanoemulsion topical vehicule:

https://pubmed.ncbi.nlm.nih.gov/38173065/

 

Edited August 18 by arthurSam

[dizzydap]

@arthurSam @4chanhrn

 

I dont think I have the option to change the carrier of the solution when it comes to compounding pharmacies..

My solution contains;

-finestride 0.25%
-minoxidil 5%
-tretinoin 0.025%

I feel like I had good gains from this however my hair loss still continues thats why I wanted to add dut instead of fin.(oral versions give me sides)

What should I do? Without changing the carrier adding dutastride would be enough?

Whats the appropriate % for dutestride

 

[Melvin- Admin]

The dalton rule is a guideline, not a set in stone rule. Molecules will penetrate if they’re bigger than 500. It needs the right vehicle. 

[Hairboy67]

I tried topical Dutasteride for 6 months, it was not effective for me. I lost more hair and had to switch back to oral finasteride to regain my loss. 

[4chanhrn]

On 8/18/2024 at 4:36 PM, dizzydap said:

@arthurSam @4chanhrn

 

I dont think I have the option to change the carrier of the solution when it comes to compounding pharmacies..

My solution contains;

-finestride 0.25%
-minoxidil 5%
-tretinoin 0.025%

I feel like I had good gains from this however my hair loss still continues thats why I wanted to add dut instead of fin.(oral versions give me sides)

What should I do? Without changing the carrier adding dutastride would be enough?

Whats the appropriate % for dutestride

 

You can switch to oral medication and/or add AR antagonist like KX if your goal is max efficacy. Topical fin should have higher efficacy vs topical dut because it goes more systemic. 

Point of topical dut is to reduce systemic absorption while keeping some efficacy with the right dose. But if you megadose it to get higher efficacy like some of the readily available highly promoted products, I'm not sure there is real advantage over taking the oral version or topical fin.

Edited August 21 by 4chanhrn