Regular Member dizzydap Posted August 18 Regular Member Share Posted August 18 Dutasteride molecular weight is 528.5 g/mol Dalton rule states the molecule needs to be under 500g/mol in order to penetrate skin Your thoughts?? Link to comment Share on other sites More sharing options...
Regular Member 4chanhrn Posted August 18 Regular Member Share Posted August 18 (edited) It penetrates but not enough. That incombination with dutasteride pharmacokynetics means it can work really well with low systemic absorption. You might find this post of my on Tressless Community interesting. I've tried to explain topical dutasteride in detail. Edited August 18 by 4chanhrn Link to comment Share on other sites More sharing options...
Regular Member arthurSam Posted August 18 Regular Member Share Posted August 18 (edited) Weight is not all, there also size wich is important. And Dalton rule is not a binary rule : it's not 0 or 1. When encapsuling dutasteride molecule within some vehicule, like lipidic carrier nanoemulsion, total molecule size are about 250 nm and can penetrate the skin: Example of a nanoemulsion topical vehicule: https://pubmed.ncbi.nlm.nih.gov/38173065/ Edited August 18 by arthurSam Minoxidil : 5% topical 1ml/day (with Melatonin 0.0033%, Fisetin 1%, Resveratrol 2%, NMN 1%, Ginko 1%, Caffein 0.2%) DHT and Follicular androgen receptor inhibitor : Topical dutasteride 0.05% once a week + Fluridil 2ml/day + Pyrilutamide Koshine826 1% 1ml/day Exosome Mesotherapy 1mm : human Umbilical Chord Exosomes ; see my progress pics here. Link to comment Share on other sites More sharing options...
Regular Member dizzydap Posted August 18 Author Regular Member Share Posted August 18 @arthurSam @4chanhrn I dont think I have the option to change the carrier of the solution when it comes to compounding pharmacies.. My solution contains; -finestride 0.25% -minoxidil 5% -tretinoin 0.025% I feel like I had good gains from this however my hair loss still continues thats why I wanted to add dut instead of fin.(oral versions give me sides) What should I do? Without changing the carrier adding dutastride would be enough? Whats the appropriate % for dutestride Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted August 19 Administrators Share Posted August 19 The dalton rule is a guideline, not a set in stone rule. Molecules will penetrate if they’re bigger than 500. It needs the right vehicle. I’m a paid admin for Hair Transplant Network. I do not receive any compensation from any clinic. My comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Hairboy67 Posted August 19 Regular Member Share Posted August 19 I tried topical Dutasteride for 6 months, it was not effective for me. I lost more hair and had to switch back to oral finasteride to regain my loss. Link to comment Share on other sites More sharing options...
Regular Member 4chanhrn Posted August 21 Regular Member Share Posted August 21 (edited) On 8/18/2024 at 4:36 PM, dizzydap said: @arthurSam @4chanhrn I dont think I have the option to change the carrier of the solution when it comes to compounding pharmacies.. My solution contains; -finestride 0.25% -minoxidil 5% -tretinoin 0.025% I feel like I had good gains from this however my hair loss still continues thats why I wanted to add dut instead of fin.(oral versions give me sides) What should I do? Without changing the carrier adding dutastride would be enough? Whats the appropriate % for dutestride You can switch to oral medication and/or add AR antagonist like KX if your goal is max efficacy. Topical fin should have higher efficacy vs topical dut because it goes more systemic. Point of topical dut is to reduce systemic absorption while keeping some efficacy with the right dose. But if you megadose it to get higher efficacy like some of the readily available highly promoted products, I'm not sure there is real advantage over taking the oral version or topical fin. Edited August 21 by 4chanhrn Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now