Regular Member Nikoni Posted July 13, 2023 Regular Member Share Posted July 13, 2023 4 hours ago, Gatchpt said: “Dr. Bloxham did the procedure, three dosages were used: 0.05 mL/5 mm 0.075 mL/5 mm 0.1 mL/5 mm at the concentration of 2 mg/mL” 3 different patients. This is what I received from a guy in some group for scars.seems the focus in this forum is more on Dr Barghouti’s trial but I think Dr Blocham FUT trial will give a definitive answer of whether this thing work or not 🤞🏽 Thanks, was there a revision of existing scar ? Link to comment Share on other sites More sharing options...
Regular Member Gatchpt Posted July 13, 2023 Regular Member Share Posted July 13, 2023 6 hours ago, Nikoni said: Thanks, was there a revision of existing scar ? Yes I think one of the patients did a revision and another case was a new FUT. but I read that the trial included a control aspect where part of the scar was removed only for comparison. If anyone in the discord can confirm my understanding it will be also helpful. Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 13, 2023 Author Administrators Share Posted July 13, 2023 Alright guys, I'm doing a live podcast with @Parsa Mohebi, MD, today at 3 PM Pacific time. Dr. Mohebi has a background in research, having been a resident at the John Hopkins Hospital. Today we'll see if he will do a trial of Verteporfin and hopefully get a date and time. I will post the live stream on here and create a separate thread for anyone who misses it. 2 1 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 14, 2023 Author Administrators Share Posted July 14, 2023 Starts at 6:30 1 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 14, 2023 Regular Member Share Posted July 14, 2023 thank you @Melvin- Moderator for pushing this forward, unfortunately no luck this time. Is there any info on Dr. Bisanga considering to try verteporfin using AI to evaluate results or he's waiting for more evidence ? 1 Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 14, 2023 Author Administrators Share Posted July 14, 2023 29 minutes ago, Nikoni said: thank you @Melvin- Moderator for pushing this forward, unfortunately no luck this time. Is there any info on Dr. Bisanga considering to try verteporfin using AI to evaluate results or he's waiting for more evidence ? I believe he’s in the same boat as Dr. Mohebi, he’s not convinced. So far, only Dr. Bloxham, Dr. Saifi, and Dr. Barghouthi have started. But Dr. Pittella said he would try it and is interested. 2 1 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 14, 2023 Regular Member Share Posted July 14, 2023 2 hours ago, Melvin- Moderator said: I believe he’s in the same boat as Dr. Mohebi, he’s not convinced. So far, only Dr. Bloxham, Dr. Saifi, and Dr. Barghouthi have started. But Dr. Pittella said he would try it and is interested. I think this is good enough for now, few trials with improving protocol each time will show if it works and to what extent. So only Dr. Barghouthi updates the results here, is there a way we can track the other trials on this forum ? Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 14, 2023 Author Administrators Share Posted July 14, 2023 6 hours ago, Nikoni said: I think this is good enough for now, few trials with improving protocol each time will show if it works and to what extent. So only Dr. Barghouthi updates the results here, is there a way we can track the other trials on this forum ? I’ll invite Dr. Bloxham, I’ve asked Killian who works with Dr. Saifi, but he doesn’t want to post here. Dr. Pittella will definitely post here. Dr. Arshad is also interested and would post here. 1 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member sr1486 Posted July 14, 2023 Regular Member Share Posted July 14, 2023 6ish more months and we should have a VERY good idea on how well this will work, based upon Dr Bloxham’s results. Fut should show without a shadow of a doubt how effective verteporfin is 1 Link to comment Share on other sites More sharing options...
Senior Member TheGreatPretender Posted July 14, 2023 Senior Member Share Posted July 14, 2023 @Melvin- Moderator Gave De Freitas the tip in my last day during surgery a week ago. He told me he was gonna have a look into it and to have a chat with you afterwards. Try to knock up a call with him or his team to see if he's up for it. 1 Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 14, 2023 Author Administrators Share Posted July 14, 2023 15 minutes ago, TheGreatPretender said: @Melvin- Moderator Gave De Freitas the tip in my last day during surgery a week ago. He told me he was gonna have a look into it and to have a chat with you afterwards. Try to knock up a call with him or his team to see if he's up for it. I’ll message his coordinator. At least if we have a multi-center study, we can know for sure whether it’s something worth pursuing or not. Lack of data doesn’t mean it doesn’t work. 7 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 15, 2023 Regular Member Share Posted July 15, 2023 Another promising study on Verteporfin that may be useful @DrTBarghouthi https://www.nature.com/articles/s41467-023-39129-6 1 Link to comment Share on other sites More sharing options...
Regular Member Square1 Posted July 15, 2023 Regular Member Share Posted July 15, 2023 On 7/14/2023 at 7:34 PM, Melvin- Moderator said: I’ll message his coordinator. At least if we have a multi-center study, we can know for sure whether it’s something worth pursuing or not. Lack of data doesn’t mean it doesn’t work. I know I have mentioned it already several times, but is there a possibility to check the original patient on his current state? If the test sites visually still look much better than the control sites, that would be a nice indication that the treatment works and passes the test of time. It's not scientific in the way people like dr. Mohebi would like to see, but still valuable I guess. What do you think about it? 2 Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 17, 2023 Regular Member Share Posted July 17, 2023 On 7/15/2023 at 9:40 PM, Square1 said: I know I have mentioned it already several times, but is there a possibility to check the original patient on his current state? If the test sites visually still look much better than the control sites, that would be a nice indication that the treatment works and passes the test of time. It's not scientific in the way people like dr. Mohebi would like to see, but still valuable I guess. What do you think about it? Hi @DrTBarghouthi, wanted to thank you again for the new trial. Are you planning a follow up with previous patient ? A lot of people are interested, but we would understand if there are difficulties with your schedule. Please just let us know. 2 Link to comment Share on other sites More sharing options...
Regular Member Fego Posted July 17, 2023 Regular Member Share Posted July 17, 2023 1 hour ago, Nikoni said: Hi @DrTBarghouthi, wanted to thank you again for the new trial. Are you planning a follow up with previous patient ? A lot of people are interested, but we would understand if there are difficulties with your schedule. Please just let us know. Yes now we are close to year Link to comment Share on other sites More sharing options...
Regular Member Gatchpt Posted July 17, 2023 Regular Member Share Posted July 17, 2023 From Dr Bloxham Discord: ”Alright, so I think I've finally caught up after the verteporfin trial and wanted to sort of unpack and just share my initial thoughts -- which I thought may be useful/interesting. So, just to recap, I did 3 separate patients, removing 1cm x 2.5cm mini-strips and directly treated (direct dermal injection with the wound open) the areas with 0.4mg/cm^2 up to 0.8mg/cm^2 verteporfin. First, I must say that the trial was a blast! It was stressful and exhausting (I recalculated and realized I was actually at the office for 16 hours straight, and not 19, but you get the point!), but truly exciting. Second, having the 4 hour window to use the reconstituted verteporfin is a bit stressful when you are dealing with multiple patients. It seems like a long time, but I was down to the wire. I had it quite well coordinated too - where I basically had it lined up so I could do all three of the excisions portions back-to-back (opposed to taking tissue and then making incisions and then placing the dissected tissue like in normal FUT) - but I still used pretty much the full 4 hours. Do I think it still would have been good after 4 hours? Yes. But I was trying to reduce variables. Reconstituing the verteporfin and preparing it in the dark room wasn't as difficult as I anticipated. So that was good. However, injecting it was challenging -- which did not surprise me too much. First, the suspension is VERY dark. Thankfully it's still translucent so you can see through it a bit, but very different from saline, lidocaine, etc -- which are all clear. This is compounded by the fact that you need to inject very small and very precise amounts. Which brings me to the actual injecting: I think injecting the first section on the first patient is something I will always remember. Again, just one of those very exciting moments for those who love science. Continued in the next post ... It's challenging to get the needle right into the dermis where you want. Very easy to go a little too far towards the deeper tissue and end up in the hypodermis or be too superficial and just get a lot of leaking of the verteporfin. Injecting is hard too because you need to pay attention to both where the needle is located and the volume at which you are injecting. So you're sort of looking back and forth rapidly -- checking the volume you are injecting and making sure the needle is in the right spot. In the future, I will probably have a spotter watch the volume for me and tell me when to stop. It would also be possible to have the correct volume in separate syringes, but then you would have dozens and dozes of these. Next, injecting the solution itself is physically hard. It's very thick and takes some real pressure to get through the needle. This is also compounded by a very fine needle (30 gauge) and a dermal injection -- the dermis is hard and injecting into it is always a little more challenging. I did try different gauge needles (27 gauge to be specific), but I'm not sure how much difference it made. I also found it variable between different patients; some had harder dermis tissue compared to others. And compound all of this with no surgical light too -- but I'll get more into that in a moment. I also found varying degrees of extravasation -- verteporfin leaking out of the injection sites. I had one patient who was bleeding more than average and had thinner blood, and he, understandably, had a bit more extravasation. I had others where the injections were super smooth: clearly in the right area, the right volumes, with very little leaking. It's also extremely cool watching the verteporfin sort of collect in the tissues because it has a very characteristic dark green color. I think we did very well with the light. I didn't use the surgical light for any aspect of the removal, injection, or closure. Continued in next post ... "I found that using magnification (7x, which I use when making recipient incisions) made up for this and I was able to visualize everything well. All of the patients responded well to the medication. No allergic reactions, no irritation reactions (apparently a pretty common one when verteporfin injection sites are exposed to intense light too soon), or anything like that. We kept everything covered well and there were no issues with the donor areas the entire day. Surgeries were unremarkable otherwise. The verteporfin treated sites looked really good at the end of the day. Even a little cleaner compared to the non-treated areas. No other real observations that early. I had them all stay pretty well covered and out of the light for 5 days. I followed up with them closely and saw them back at the office multiple times since the test and everything is great without any issues. So I feel very good about the safely profile of the verteporfin (which was pretty well established regardless). There also did not seem to be any problem going up to nearly double the dose used in tests thus far (0.8mg/cm^2). I spoke about this with several knowledgeable colleagues (including Dr Barghouthi) and felt good about it -- and it seems like that hunch was correct. We will see if it makes a difference with regard to healing. So, altogether, I felt quite good with the first trial and I want to do more regardless of outcome. I think I can definitely do better on subsequent rounds (the first time at anything is obviously always never quite as smooth!). I also want to test the other aspects of verteporfin as well. Next tests will probably be a bigger punch left open to see how it heals/check for regeneration, and then I would love to do some wounding with dermarolling or something like that in the recipient area and then treat with verteporfin to see how it does. Last post below ... I wanted to, again, thank everyone on the server. You guys have been great! I also would love to be included on any other sites, forums, apps, etc where you share future treatment information. I'm always impressed on how quickly you guys find this new stuff! Any other thoughts on where else I should share this? I know there have been some threads on hair restoraiton network. It looks like it's kind of the last forum standing? Hair Loss Talk previously had all the "future" treatment discussion, but I think that one is gone now! I'm going to document everything through YouTube as well. I'll make the announcement video this week and then update with 48 hour pictures, staple removal pictures, etc. And, of course, I will keep this server the most updated and share everything here first." 8 2 Link to comment Share on other sites More sharing options...
Regular Member tatasabaya Posted July 18, 2023 Regular Member Share Posted July 18, 2023 1 hour ago, Gatchpt said: From Dr Bloxham Discord: ”Alright, so I think I've finally caught up after the verteporfin trial and wanted to sort of unpack and just share my initial thoughts -- which I thought may be useful/interesting. So, just to recap, I did 3 separate patients, removing 1cm x 2.5cm mini-strips and directly treated (direct dermal injection with the wound open) the areas with 0.4mg/cm^2 up to 0.8mg/cm^2 verteporfin. First, I must say that the trial was a blast! It was stressful and exhausting (I recalculated and realized I was actually at the office for 16 hours straight, and not 19, but you get the point!), but truly exciting. Second, having the 4 hour window to use the reconstituted verteporfin is a bit stressful when you are dealing with multiple patients. It seems like a long time, but I was down to the wire. I had it quite well coordinated too - where I basically had it lined up so I could do all three of the excisions portions back-to-back (opposed to taking tissue and then making incisions and then placing the dissected tissue like in normal FUT) - but I still used pretty much the full 4 hours. Do I think it still would have been good after 4 hours? Yes. But I was trying to reduce variables. Reconstituing the verteporfin and preparing it in the dark room wasn't as difficult as I anticipated. So that was good. However, injecting it was challenging -- which did not surprise me too much. First, the suspension is VERY dark. Thankfully it's still translucent so you can see through it a bit, but very different from saline, lidocaine, etc -- which are all clear. This is compounded by the fact that you need to inject very small and very precise amounts. Which brings me to the actual injecting: I think injecting the first section on the first patient is something I will always remember. Again, just one of those very exciting moments for those who love science. Continued in the next post ... It's challenging to get the needle right into the dermis where you want. Very easy to go a little too far towards the deeper tissue and end up in the hypodermis or be too superficial and just get a lot of leaking of the verteporfin. Injecting is hard too because you need to pay attention to both where the needle is located and the volume at which you are injecting. So you're sort of looking back and forth rapidly -- checking the volume you are injecting and making sure the needle is in the right spot. In the future, I will probably have a spotter watch the volume for me and tell me when to stop. It would also be possible to have the correct volume in separate syringes, but then you would have dozens and dozes of these. Next, injecting the solution itself is physically hard. It's very thick and takes some real pressure to get through the needle. This is also compounded by a very fine needle (30 gauge) and a dermal injection -- the dermis is hard and injecting into it is always a little more challenging. I did try different gauge needles (27 gauge to be specific), but I'm not sure how much difference it made. I also found it variable between different patients; some had harder dermis tissue compared to others. And compound all of this with no surgical light too -- but I'll get more into that in a moment. I also found varying degrees of extravasation -- verteporfin leaking out of the injection sites. I had one patient who was bleeding more than average and had thinner blood, and he, understandably, had a bit more extravasation. I had others where the injections were super smooth: clearly in the right area, the right volumes, with very little leaking. It's also extremely cool watching the verteporfin sort of collect in the tissues because it has a very characteristic dark green color. I think we did very well with the light. I didn't use the surgical light for any aspect of the removal, injection, or closure. Continued in next post ... "I found that using magnification (7x, which I use when making recipient incisions) made up for this and I was able to visualize everything well. All of the patients responded well to the medication. No allergic reactions, no irritation reactions (apparently a pretty common one when verteporfin injection sites are exposed to intense light too soon), or anything like that. We kept everything covered well and there were no issues with the donor areas the entire day. Surgeries were unremarkable otherwise. The verteporfin treated sites looked really good at the end of the day. Even a little cleaner compared to the non-treated areas. No other real observations that early. I had them all stay pretty well covered and out of the light for 5 days. I followed up with them closely and saw them back at the office multiple times since the test and everything is great without any issues. So I feel very good about the safely profile of the verteporfin (which was pretty well established regardless). There also did not seem to be any problem going up to nearly double the dose used in tests thus far (0.8mg/cm^2). I spoke about this with several knowledgeable colleagues (including Dr Barghouthi) and felt good about it -- and it seems like that hunch was correct. We will see if it makes a difference with regard to healing. So, altogether, I felt quite good with the first trial and I want to do more regardless of outcome. I think I can definitely do better on subsequent rounds (the first time at anything is obviously always never quite as smooth!). I also want to test the other aspects of verteporfin as well. Next tests will probably be a bigger punch left open to see how it heals/check for regeneration, and then I would love to do some wounding with dermarolling or something like that in the recipient area and then treat with verteporfin to see how it does. Last post below ... I wanted to, again, thank everyone on the server. You guys have been great! I also would love to be included on any other sites, forums, apps, etc where you share future treatment information. I'm always impressed on how quickly you guys find this new stuff! Any other thoughts on where else I should share this? I know there have been some threads on hair restoraiton network. It looks like it's kind of the last forum standing? Hair Loss Talk previously had all the "future" treatment discussion, but I think that one is gone now! I'm going to document everything through YouTube as well. I'll make the announcement video this week and then update with 48 hour pictures, staple removal pictures, etc. And, of course, I will keep this server the most updated and share everything here first." Thank you! Is that an open discord server? And is this the youtube channel he's referring to? https://www.youtube.com/@fellerandbloxham Link to comment Share on other sites More sharing options...
Regular Member sr1486 Posted July 18, 2023 Regular Member Share Posted July 18, 2023 We are so back Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted July 18, 2023 Share Posted July 18, 2023 12 hours ago, Nikoni said: Hi @DrTBarghouthi, wanted to thank you again for the new trial. Are you planning a follow up with previous patient ? A lot of people are interested, but we would understand if there are difficulties with your schedule. Please just let us know. Thanks guys. Yes ofcourse, but the patient when contacted was on holidays away. I will have him checked when he gets back ofcourse. 1 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
MAGNUS Posted July 18, 2023 Share Posted July 18, 2023 On 7/15/2023 at 12:33 PM, Nikoni said: Another promising study on Verteporfin that may be useful @DrTBarghouthi https://www.nature.com/articles/s41467-023-39129-6 I've seen this study posted twice in the past few weeks. It does seem pretty promising, even though it only looks at mice/rabbit models. It should also be noted that it is published in a reputable journal. Given the challenges that Dr Bloxham noted above in administering Verteporfin in the latest trial, I was wondering if there would be any interest in trying to use these micro-needling patches filled with Verteporfin in subsequent trials? They may be very difficult to get hold of, but it might be worth more investigation. Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 18, 2023 Regular Member Share Posted July 18, 2023 Longaker had an update in May. Planning to get FDA approval for scar revision, filed for an IP and will be doing children cleft lip revision. Seems to be a good sign. What do you think ?https://doctrc.org/wp-content/uploads/2023/05/Cleft-Lip-Revision-Drug-Longaker.pdf Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted July 18, 2023 Author Administrators Share Posted July 18, 2023 ATTENTION: Guys, can someone please get me Dr. Longakers contact information? It would be invaluable to our cause to get him on a podcast and talk about the potential of Verteporfin for hair restoration. EDIT: I found this longaker@stanford.edu Everyone who sees this, send him an email with this thread and ask him to be on our podcast. Perhaps, getting him to explain the science correctly can help convince more surgeons to join. 3 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member -TheHairUpThere- Posted July 18, 2023 Regular Member Share Posted July 18, 2023 So Dr bloxham also did injections on an already healed scar correct?.....that might be the most interesting case of all. Preventing scarring is one thing. But being able to regrow hair on an already existing scar would be truly mind blowing. Basically gives thousands of guys who exhausted all their donor hair brand new life. 1 Link to comment Share on other sites More sharing options...
Senior Member mr_peanutbutter Posted July 18, 2023 Senior Member Share Posted July 18, 2023 39 minutes ago, Melvin- Moderator said: ATTENTION: Guys, can someone please get me Dr. Longakers contact information? It would be invaluable to our cause to get him on a podcast and talk about the potential of Verteporfin for hair restoration. EDIT: I found this longaker@stanford.edu Everyone who sees this, send him an email with this thread and ask him to be on our podcast. Perhaps, getting him to explain the science correctly can help convince more surgeons to join. amazing idea, will link him this thread 1 Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted July 19, 2023 Regular Member Share Posted July 19, 2023 Maybe guys like Elon Musk, Joe Rogan can support this ? They have visible HT scars. Can anyone somehow reach to them ? @Melvin- Moderator 1 Link to comment Share on other sites More sharing options...
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