Regular Member Nikoni Posted October 27, 2023 Regular Member Share Posted October 27, 2023 @Melvin- Admin is it possible to arrange a podcast with Dr. Barghouthi after his trial ? There are so many questions. Also maybe you can arrange one also with Dr. Bloxham. I am sure these podcasts will be hits. BTW Dr. Barghouthi said that trial date is October 24, do you know if it was done ? 2 Link to comment Share on other sites More sharing options...
Regular Member TV_on_LazerDisk Posted October 27, 2023 Regular Member Share Posted October 27, 2023 21 hours ago, takuma said: We next assessed the effects of multiple verteporfin doses. Treatment with two doses (POD 0 and 4) yielded healing rates, gross appearance, ECM, and EPF abundances comparable to single-dose effects (POD 0) (fig. S7). When dosage was increased to four treatments (POD 0, 4, 8, and 12), EPFs were almost fully depleted (fig. S7, D and E) but wound closure was delayed, hair regrowth was reduced, and ECM features diverged from those of unwounded skin (fig. S7, A to C). Thus, verteporfin affected wounds in a dose-dependent manner, with detrimental effects upon excessive dosing. Despite scars’ excess collagen, they possess ≤80% of skin’s strength because of inferior ECM organization (26). We sought to determine whether verteporfin-induced regeneration also functionally recovered skin’s mechanical robustness. Consistent with scars’ decreased structural integrity, POD 30 control wounds had significantly reduced tensile strength (versus skin; Fig. 4I, green versus red). In contrast, verteporfin-treated wounds’ tensile strength did not significantly differ from that of unwounded skin (Fig. 4I, green versus blue), supporting restoration of unwounded-like strength (representative force-displacement/stress-strain curves, fig. S12). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008875/ From my understanding here, when the researchers tried multiple doses it had reduced hair regeneration and too long delayed the wound closure, but im not sure if this means they tried multiple doses at once or if they tried to do so within longer time intervals ie days or weeks. But, my assumption is they spaced it out because they mentioned four treatments implying they treated the wound with verteporfin four different times in that attempt I posted the study for reference I think hgh during the healing period might be an option. Should accelerate wound healing and tissue regeneration possibly hair follicles. Link to comment Share on other sites More sharing options...
Regular Member takuma Posted October 28, 2023 Regular Member Share Posted October 28, 2023 there's something that confuses me, so when we get a hair transplant the surgeon punches tiny holes in the scalp donor region and extracts follicles and when the skin heals it leaves scar tissue which doesn't grow hair. But, the surgeon also makes incisions in the recipient area at the top of the scalp and inserts the extracted follicles into those incisions, correct. So why does the hair grow back, after all the surgeon is wounding both areas, shouldnt the skin in both areas grow back as scarred skin that is unable to grow hair from it, or am i missing something Link to comment Share on other sites More sharing options...
Regular Member victorcitolago Posted October 28, 2023 Regular Member Share Posted October 28, 2023 There is a study that I went through not long ago and in which it was shown precisely that (the study was also done by a Spanish and an English hair surgeon) how when grafting hair into a scar, this hair follicle changed the molecular structure of the scar tissue resembling it to healthy tissue, since this follicle when it "grabbed" in the skin caused sweat glands to grow. blood vessels to provide irrigation to the new hair, sebaceous glands, etc., so this in turn transformed the scar tissue into normal tissue. 1 Link to comment Share on other sites More sharing options...
Regular Member victorcitolago Posted October 28, 2023 Regular Member Share Posted October 28, 2023 https://www.google.com/amp/s/www.imperial.ac.uk/news/242531/scars-mended-using-transplanted-hair-follicles/amp/ 1 Link to comment Share on other sites More sharing options...
Regular Member tatasabaya Posted October 28, 2023 Regular Member Share Posted October 28, 2023 7 hours ago, takuma said: there's something that confuses me, so when we get a hair transplant the surgeon punches tiny holes in the scalp donor region and extracts follicles and when the skin heals it leaves scar tissue which doesn't grow hair. But, the surgeon also makes incisions in the recipient area at the top of the scalp and inserts the extracted follicles into those incisions, correct. So why does the hair grow back, after all the surgeon is wounding both areas, shouldnt the skin in both areas grow back as scarred skin that is unable to grow hair from it, or am i missing something Because they insert the grafted healthy skin with the hair follicle. There's no "hole" left in the recipient area. 1 Link to comment Share on other sites More sharing options...
Regular Member sansi Posted October 29, 2023 Regular Member Share Posted October 29, 2023 On 10/16/2023 at 8:04 PM, DrTBarghouthi said: Hi guys, Apologies for the delay. I like to process the photos myself and I couldn’t get to that yet in clinic. Nonetheless, I know most of you are waiting for some sort of update. I had a look at the areas and the patient and I must say I’m quite happy with how the 0.4 mg and to some extent the 0.32 mg areas have developed. The 0.4 mg I found to be nicely healed . I will share the photos ofcourse but thought at least to give some update of what I saw thus far. @DrTBarghouthi you are being harsh on us after such an encouraging update we haven't seen photos for two weeks already. 2 5 Link to comment Share on other sites More sharing options...
Regular Member sansi Posted October 29, 2023 Regular Member Share Posted October 29, 2023 Guys why do you dislike my comment ? I am very encouraged and want to see the photos of the healed area . Asking for an update does not equal to disrespect and I am as grateful to Doctor Barghouthi as you. 4 1 Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted October 30, 2023 Author Administrators Share Posted October 30, 2023 @sansi While I appreciate your enthusiasm. Dr. Barghouthi is well aware that people are expecting to see an update. Constantly asking him for an update isn’t going to make it happen any faster. That doesn’t mean he’s being harsh, it means he’s busy and hasn’t had the time. Patience is key. 2 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member takuma Posted October 31, 2023 Regular Member Share Posted October 31, 2023 So far it's two surgeons, Doctor Bargouthi and Doctor Bloxham that are actively experimenting with verteporfin on hair transplant patients, Have any other doctor's expressed interest? Does anyone know. Link to comment Share on other sites More sharing options...
Regular Member tatasabaya Posted October 31, 2023 Regular Member Share Posted October 31, 2023 (edited) 14 minutes ago, takuma said: So far it's two surgeons, Doctor Bargouthi and Doctor Bloxham that are actively experimenting with verteporfin on hair transplant patients, Have any other doctor's expressed interest? Does anyone know. Dr. Pittella and Dr Parissis afaik. They expressed interest but that's all, no plans have been made public so far. Edited October 31, 2023 by tatasabaya 2 Link to comment Share on other sites More sharing options...
DrTBarghouthi Posted November 1, 2023 Share Posted November 1, 2023 Hi guys, Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. 19 2 2 1 Dr. Taleb Barghouthi approved and recommended on the Hair Transplant Network. You can schedule a virtual consultation with me here. Contact me via WhatsApp at +962798378396 (Jordan) Social media: Facebook YouTube Twitter Instagram Link to comment Share on other sites More sharing options...
piruka Posted November 1, 2023 Share Posted November 1, 2023 That is amazing! The 0.4T looks untouched to my eyes. Seems like it can actually regrow hairs 😲 Worth the wait, thanks for doing this. You’re a legend 1 Link to comment Share on other sites More sharing options...
Senior Member mr_peanutbutter Posted November 1, 2023 Senior Member Share Posted November 1, 2023 (edited) 27 minutes ago, DrTBarghouthi said: Hi guys, Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. holy smoke, the difference is undeniable. big thanks for taking the risk and actually doing this DR. BARGHOUTHI! did colleagues already approached you during the conference in india? if that really world i hereby official endorse you, melvin and the donator for the nobel price in medicine Edited November 1, 2023 by mr_peanutbutter Link to comment Share on other sites More sharing options...
Regular Member Fox243 Posted November 1, 2023 Regular Member Share Posted November 1, 2023 29 minutes ago, DrTBarghouthi said: Hi guys, Hope you’re keeping well. Apologies for keeping you waiting again. It was a busier than usual period in the last few weeks and I just landed in India for the annual hair conference. As mentioned in a previous post, I continue to see the consistent difference between injected and control sites. I think the 0.4 area has been showing the best overall progress- but I also think that we do notice changes in the other doses too. The zoomed out 0.4 area looks to me untouched- but that’s only my subjective judgement. I was also happy to see the 0.24 mg area catching up to show better visual recovery and that might be due to the fact that this area had tumescent fluids injected in it, leading to vasoconstriction. This might be leading to a more localised effect of Verteporfin in the region. I have uploaded the photos here. As for future trials, I had one planned for the 24 th October, but I pushed him back because of the conference. I thought it would be important to follow him closely in the first few weeks and I didn’t want to be away in his initial recovery. We agreed to do it in November as he also has no travel commitments or difficulties with regular follow ups. We also have another patient who will be potentially having Verteporfin in November along with his procedure. I think the optimal dosing is not too far off. I am still keen on increasing the dose slightly- or at least in some areas. Dang we might be cured bois 1 1 Link to comment Share on other sites More sharing options...
Valued Contributor Gatsby Posted November 1, 2023 Valued Contributor Share Posted November 1, 2023 You're doing God's work @DrTBarghouthi. 🙌💯 GATSBY 'UNPLUGGED!' 15,671 (3 surgeries) Grafts FUE+BHT Dr. Sethi Eugenix Link to comment Share on other sites More sharing options...
Regular Member Square1 Posted November 1, 2023 Regular Member Share Posted November 1, 2023 To play devil's advocate. I think that the test-site for 0.4 does not look completely untouched. To me, the density is visually lower than the part of the head above that was actually untouched. Dose optimization is still an issue it seems. However, the test-site lacks the open holes that the control site clearly has, so the most logical outcome is that considerable regrowth has taken place. Also very positive is that this regrown hair is still here after give or take 16 months. Fantastic that more research is in the pipeline. Does it include more scientific hair count measurements? If so, we can put a percentage on the hair it regrows and gives an benchmark for other scientists to improve upon. Overall, great news and many thanks again for the work of dr. Barghouthi. What percentage of regrowth do you think is achieved here? 1 Link to comment Share on other sites More sharing options...
Regular Member takuma Posted November 1, 2023 Regular Member Share Posted November 1, 2023 (edited) i am absolutely floored by the 0.4T pics! wow! just amazing. Thank you so much Doctor Bargouthi for doing these trials @DrTBarghouthi Edited November 1, 2023 by takuma Link to comment Share on other sites More sharing options...
Regular Member Eli_Avdikian Posted November 1, 2023 Regular Member Share Posted November 1, 2023 Amazing ! beyond words ! Link to comment Share on other sites More sharing options...
Administrators Melvin- Admin Posted November 1, 2023 Author Administrators Share Posted November 1, 2023 Promising indeed hopefully you can speak about this at the conference @DrTBarghouthi 🙏 3 Quote I was just an inch away from booking a a hairmill based on google reviews before i stumbled upon this goldmine of a forum. I’m a paid administrator for Hair Transplant Network. I do not receive compensation from any clinic, and my comments are not medical advice. Check out my final hair transplant and topical dutasteride journey: View my thread Topical dutasteride journey Melvin- Managing Publisher and Forum Moderator for the Hair Transplant Network, the Coalition Hair Loss Learning Center, and the Hair Loss Q&A Blog. Follow our Social Media: Facebook, Instagram, Linkedin, and YouTube. Link to comment Share on other sites More sharing options...
Regular Member takuma Posted November 1, 2023 Regular Member Share Posted November 1, 2023 Guys, we should have a verteporfin + microneedling test done on a completely bald region on the top of the head test with verteporfin. Would be interesting if it works on completely bald areas as well. Maybe we should get a bottle on a group buy and test it Link to comment Share on other sites More sharing options...
Regular Member Nikoni Posted November 1, 2023 Regular Member Share Posted November 1, 2023 Totally worth the wait !!! You cracked it Dr. Barghouthi from the very first attempt. 1 Link to comment Share on other sites More sharing options...
Regular Member takuma Posted November 1, 2023 Regular Member Share Posted November 1, 2023 (edited) Apart from the hair regeneration, which is pretty obvious from the comparison, It's amazing too how there is virtually no scars in the 0.4T and 0.32T verteporfin tested area pics wow! Even on the 0.24T test pics you can see that it looks different, less scarring. Wowowow! Edited November 1, 2023 by takuma Link to comment Share on other sites More sharing options...
Regular Member sr1486 Posted November 1, 2023 Regular Member Share Posted November 1, 2023 I’m very happy. I hope I can get a transplant with verteporfin in the next year or so 1 Link to comment Share on other sites More sharing options...
Senior Member TorontoMan Posted November 1, 2023 Senior Member Share Posted November 1, 2023 Exciting news, selfishly now I’d like to know if it would work on donor regions that have already been extracted from 2 Link to comment Share on other sites More sharing options...
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